Monday, December 7, 2020

Celebration of Life: Macrine J. Katague via her Favorite Music ( Tangos)-Part 11

 This is Part 11 out of 14 on the series, Macrine J.Katague, Celebration of Life.


Macrine and I dancing the Rumba, Boac, Marinduque, 2011

Macrine and I dancing the Tango during the PAFC Gala, Washington DC, 1999

Macrine and I loved to dance the Tango, Cha Cha and Rumba. A few decades ago while we were vacationing in Miami Beach, Florida staying at the Fontainebleau Hotel*, we participated in a dance contest. We won first place dancing the Cha Cha. But Tango is our favorite dance and La Cumparsita is our favorite tango music. In this episode I am posting two version of La Cumparsita(instrumental and vocal).     



Meanwhile enjoy this Tango music, El Choclo sang by Julio Iglesias


Tango music also reminds me of Macrine's first cousin Yong Nieva and wife Ivy Almario and their Beach Resort, Amana in Cawit, Marinduque

 

Macrine and I with Yong Nieva, Amana Resort, Marinduque, 2011
 

http://livinginmarinduquephilippines.blogspot.com/2012/11/improve-your-sex-life-by-dancing.html

A Short History of Fontainebleau Hotel

*Envisioning the creation of one of the most opulent and magnificent hotels in the world, hotelier Ben Novack purchased the Firestone Mansion, home of auto tire magnate Harvey Firestone in 1952 for $2.3 million. He tapped Morris Lapidus, who was known for his modernist sensibilities and flair for theatrical spaces, to be the hotel’s project architect. When it opened in 1954, Fontainebleau Miami Beach was the largest and most luxurious hotel in South Florida. Located on the oceanfront in the heart of Millionaire's Row, Fontainebleau Miami Beach is one of the most historically and architecturally significant hotels on Miami Beach. Its signature features included a 17,000-square-foot lobby with the now-legendary “Stairway to Nowhere,” six acres of formal gardens designed to replicate Versailles and thousands of dollars in antique furnishings to authentically convey the hotel’s French period theme.

Through the 1950s and 1960s, the hotel reigned as Miami’s leading resort and Lapidus’ gently curving façade came to symbolize the very essence of glamorous Miami Beach. For nearly 25 years, the Miami Beach hotel was so well-known that no sign was necessary to identify it. Celebrities and entertainers, ranging from Elvis Presley and Bob Hope to Lucille Ball and Judy Garland, made the hotel so popular that Novack was once forced to post armed guards to bar non-guests from entering.

At that time we were not aware of the above history. However, we know we were staying in a luxurious hotel. This is an example of our lives well lived. Rest in Peace, My Love!! For more details on Tangos read:

https://marinduqueawaitsyou.blogspot.com/search?q=tango

 

Saturday, December 5, 2020

Have You Heard of CRISPR Gene Editing Technology?

 


Just recently, I was watching CNN Fareed Zakaria Sunday Talk#. On this recent episode his guest was 2020 Nobel Prize Winner in Chemistry, Jennifer Doudna of UC Berkeley-one of my Alma Mater schools.

The interview was about CRISPR technology of creation of new medicines, agricultural products, controlling pathogens and pest as wells the controversial subject of editing human embryos to produce super/designer babies. This aroused my interest so in case you are not familiar with this subject, here's a brief summary from Wikipedia. 

CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats) Gene Editing is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified. It is based on a simplified version of the bacterial CRISPR-Cas9 antiviral defense system. By delivering the Cas9 nuclease complexed with a synthetic guide RNA (gRNA) into a cell, the cell's genome can be cut at a desired location, allowing existing genes to be removed and/or new ones added in vivo (in living organisms).

The technique is considered highly significant in biotechnology and medicine as it allows for the genomes to be edited in vivo with extremely high precision, cheaply and with ease. It can be used in the creation of new medicines, agricultural products, and genetically modified organisms, or as a means of controlling pathogens and pests. It also has possibilities in the treatment of inherited genetic diseases as well as diseases arising from somatic mutations such as cancer. 

However, its use in human germline genetic modification(designer babies) is highly controversial. 

The development of the technique earned Jennifer Doudna and Emmanuelle Charpentier the Nobel Prize in Chemistry in 2020. The third researcher group that shared the Kavli Prize for the same discovery (led by Virginijus Šikšnys) was not awarded the Nobel prize.

In 2012 and 2013, CRISPR was a runner-up in Science Magazine's Breakthrough of the Year award. In 2015, it was the winner of that award. CRISPR was named as one of MIT Technology Review's 10 breakthrough technologies in 2014 and 2016. In 2016, Jennifer Doudna and Emmanuelle Charpentier, along with Rudolph Barrangou, Philippe Horvath, and Feng Zhang won the Gairdner International award. In 2017, Doudna and Charpentier were awarded the Japan Prize in Tokyo, Japan for their revolutionary invention of CRISPR-Cas9. In 2016, Charpentier, Doudna, and Zhang won the Tang Prize in Biopharmaceutical Science. In 2020, Charpentier and Doudna were awarded the Nobel Prize in Chemistry "for the development of a method for genome editing." 


 https://www.youtube.com/watch?v=2pp17E4E-O8

For more details visit:

https://en.wikipedia.org/wiki/CRISPR_gene_editing 

Meanwhile for a less complicated subject, enjoy this:


#https://www.cnn.com/videos/tv/2020/11/08/exp-gps-1108-fareeds-take.cnn

 

Tuesday, December 1, 2020

Celebration of Life: Macrine J. Katague via her Favorite Music (Hymns)-Part 10

This is Part 10 of the 14 Series on Macrine J. Katague, Celebration of Life.

Macrine loved to sing. In her younger years, she sings coloratura soprano. When she started smoking later in her forties ( during nursing school), her voice changed to mezzo soprano. Macrine and I loved singing in the choir here in Northern California. In the late 1980's, we sang in our church choir on Sunday masses in Pinole, as well as with the UP Alumni, Berkeley Chapter Choir based in El Sobrante, California.

Eleven years ago, we sang in our Church Choir here in Fair Oaks. We even sang a duet of Silent Night in Tagalog at the concert before the Christmas midnight mass. Macrine and I had also organized the Marinduque Association of the Capital Area( MACA) Christmas Caroling Group in Colesville, Maryland in the late 1990's.

Besides singing in the church Choir with me, Macrine sang a few times during a friends wedding and she got paid, so I will consider her a semi-pro. Anyway in this episode, I am posting two of her favorite hymns that we sometimes sung during Catholic masses.  Make a Channel of your Peace( the Prayers of St.Francis), and On Eagle Wings..

  

The Prayer of St Francis song (Make me a Channel of your Peace)reminds me of our one week vacation in Rome and in the Vatican, and our visit to Assissi, Italy in 1990

On Eagle Wings reminds me of our one week vacation in Aruba, 2001

Meanwhile, while searching for the best arrangement of the above two songs, I found two renditions of Cohen's Hallelujah as follows:

Celine Dion surprises the Canadian Tenors-Oprah in the Audience 

Religious Hymns reminds me of our college years and the University of the Philippines Student Catholic activities, 1951-1955.

https://davidbkatague.blogspot.com/search?q=UPSCA

Meanwhile, enjoy this photo from Chateau Du Mer, Boac, Marinduque, Philippines-our second home!!


 

 

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